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On the opposing side, the Serie A leaders will rely on their top goal scorer and playmaker to make the difference. With a potent attack led by their star striker and solid midfield presence, they will pose a formidable challenge to Real Madrid's backline.The FDA approved acellular tissue engineered vessel-tyod (Symvess, Atev; Humacyte Inc) for use in adults as a vascular conduit for extremity arterial injury when urgent revascularization is needed to avoid imminent limb loss and when autologous vein graft is not feasible. The approval follows positive results from the pivotal phase 2/3 V005 (NCT03005418) clinical trial. Image credit: JHVEPhoto | stock.adobe.com Humacyte Human Acellular Vessel (HAV) in Patients With Vascular Trauma NCT03005418 Humacyte, Inc. September 1, 2027 Symvess is a first-in-class bioengineered human tissue that is designed to be a universally implantable vascular conduit for use in arterial replacement and repair. Because harvesting vein from a trauma patient can take time during surgery, Symvess is available off-the-shelf, which does not require potential further injury to the patient to obtain vascular repair material via an invasive surgery. The Symvess trauma program was granted regenerative medicine advanced therapy designation by the FDA in May 2023, and in February 2024, it received a priority review. “The approval of a vascular conduit that resists infection and remodels into native arteries is an extraordinary technological advancement that will have a huge impact on the quality of trauma care around the world,” Charles J. Fox, MD, FACS, director of Vascular Surgery at the University of Maryland Capital Region, said in a news release. “Symvess is perfectly sized to treat most injuries, has excellent handling properties, and reduces time necessary to save both life and limbs.” The V005 (NCT03005418) trial, also called CLN-PRO-V005, is a prospective, multicenter, multi-cohort, non-randomized phase 2/3 study which enrolled patients with life- or limb-threatening vascular trauma which requires surgical repair. A limb cohort includes patients who require repair of a vessel contained to the upper or lower extremity, and a torso cohort includes patients who require repair of vessels within the thorax (excluding the heart), abdomen, and retroperitoneum. No control arms are included in this study. All patients received the investigational Symvess, which were used for arterial bypass or reconstruction. The device is implanted using a standard vascular surgical technique, similar to those used to place predicate peripheral vascular prostheses. The primary outcome measures are primary patency (defined as the interval from the time of access placement until any intervention designed to maintain or reestablish patency, access thrombosis or the measurement of patency), which was assessed at 30 days, and frequency and severity of adverse events (AEs), which was assessed at 36 months. A total of 69 patients with a mean age of 33.5 years were enrolled in the trial, of which the majority were male (n = 38). At day 30, the primary patency was approximately 84.3% (95% CI, 72.0%-91.8%) and secondary patency was 90.2% (95% CI, 79.0%-95.7%). Additionally, amputation rate was about 9.8% (95% CI, 4.3%-21.0%). Infection and death rates were also low, occurring in about 2.0% (95% CI, 0.4%-10.3%) and 5.9% (95% CI, 2.0%-15.9%) of patients, respectively. “I believe that Symvess will revolutionize vascular trauma care and be profoundly beneficial to our patients,” Rishi Kundi, MD, surgical critical care of vascular surgery at the University of Maryland Medical System, said in the news release. “From my experience so far, Symvess will allow reconstructions that are currently impracticable because of contamination and infection. It will make reconstructions that we now perform with prosthetic or even biologic grafts more successful.” Overall, AEs and serious AEs were frequent in V005 consistent with patients with acute injuries. According to the investigators, AEs of special interest, including thrombosis, rupture, aneurysm, and pseudoaneurysm, occurred at acceptable rates that were consistent with reports of other vascular conduits, including autologous vein and synthetic grafts. At 30 days, AEs of interest were reported for 8 patients and included thromboses and occlusions (resolved or unresolved), nonspontaneous rupture (n = 1), and infection of the conduit (n = 1). Additionally, all enrolled patients receiving Symvess presented multiple risk factors that could lead to wound infection, of which 20 patients developed 1 or more infectious events by day 30 (eg, bacteremia, fungemia, sepsis, and osteomyelitis). “The FDA approval of Symvess will make it the preferred conduit for complex vascular injuries, and particularly those at risk for infection,” Ernest E. Moore, MD, FACS, director of Research at the Ernest E. Moore Shock Trauma Center at Denver Health, said in the news release.
This strategic move not only reflects the club's commitment to promoting women's football but also underscores their financial acumen in capitalizing on their global fan base to generate substantial revenue. By offering VIP box pre-sales, FC Barcelona is not only providing their loyal supporters with exclusive access to premium seating and amenities at Camp Nou but also securing a lucrative revenue stream that will support the registration of the women's team in the top division.The financial impact of Manson Market's closure is significant, with over 25,000 euros believed to have been laundered through the platform over the course of its operation. This money was generated through the sale of stolen credit card information, personal data, and other illegal products, highlighting the lucrative nature of cybercrime.
Nasdaq Announces End-of-Month Open Short Interest Positions in Nasdaq Stocks as of Settlement Date November 29, 2024The news of TSMC's successful trial production and high yield rate for its 2nm chips has sparked optimism about the company's ability to commence mass production next year. If TSMC can maintain its current pace and overcome any potential challenges, the 2nm chips could potentially revolutionize the semiconductor market with their advanced capabilities. The prospect of mass production of 2nm chips signifies a significant step forward in the development of next-generation technology.
NEW YORK (AP) — President-elect Donald Trump’s recent dinner with Canadian Prime Minister Justin Trudeau and his visit to Paris for the reopening of the Notre Dame Cathedral were not just exercises in policy and diplomacy. They were also prime trolling opportunities for Trump. Throughout his first term in the White House and during his campaign to return, Trump has spun out countless provocative, antagonizing and mocking statements. There were his belittling nicknames for political opponents, his impressions of other political figures and the plentiful memes he shared on social media. Now that's he's preparing to return to the Oval Office, Trump is back at it, and his trolling is attracting more attention — and eyerolls. On Sunday, Trump turned a photo of himself seated near a smiling first lady Jill Biden at the Notre Dame ceremony into a social media promo for his new perfume and cologne line, with the tag line, “A fragrance your enemies can’t resist!” The first lady’s office declined to comment. When Trudeau hastily flew to Florida to meet with Trump last month over the president-elect's threat to impose a 25% tax on all Canadian products entering the U.S., the Republican tossed out the idea that Canada become the 51st U.S. state. The Canadians passed off the comment as a joke, but Trump has continued to play up the dig, including in a post Tuesday morning on his social media network referring to the prime minister as “Governor Justin Trudeau of the Great State of Canada.” After decades as an entertainer and tabloid fixture, Trump has a flair for the provocative that is aimed at attracting attention and, in his most recent incarnation as a politician, mobilizing fans. He has long relished poking at his opponents, both to demean and minimize them and to delight supporters who share his irreverent comments and posts widely online and cheer for them in person. Trump, to the joy of his fans, first publicly needled Canada on his social media network a week ago when he posted an AI-generated image that showed him standing on a mountain with a Canadian flag next to him and the caption “Oh Canada!” After his latest post, Canadian Immigration Minister Marc Miller said Tuesday: “It sounds like we’re living in a episode of South Park." Trudeau said earlier this week that when it comes to Trump, “his approach will often be to challenge people, to destabilize a negotiating partner, to offer uncertainty and even sometimes a bit of chaos into the well established hallways of democracies and institutions and one of the most important things for us to do is not to freak out, not to panic.” Even Thanksgiving dinner isn't a trolling-free zone for Trump's adversaries. On Thanksgiving Day, Trump posted a movie clip from “National Lampoon’s Christmas Vacation” with President Joe Biden and other Democrats’ faces superimposed on the characters in a spoof of the turkey-carving scene. The video shows Trump appearing to explode out of the turkey in a swirl of purple sparks, with the former president stiffly dancing to one of his favorite songs, Village People’s “Y.M.C.A." In his most recent presidential campaign, Trump mocked Florida Gov. Ron DeSantis, refusing to call his GOP primary opponent by his real name and instead dubbing him “Ron DeSanctimonious.” He added, for good measure, in a post on his Truth Social network: “I will never call Ron DeSanctimonious ‘Meatball’ Ron, as the Fake News is insisting I will.” As he campaigned against Biden, Trump taunted him in online posts and with comments and impressions at his rallies, deriding the president over his intellect, his walk, his golf game and even his beach body. After Vice President Kamala Harris took over Biden's spot as the Democratic nominee, Trump repeatedly suggested she never worked at McDonalds while in college. Trump, true to form, turned his mocking into a spectacle by appearing at a Pennsylvania McDonalds in October, when he manned the fries station and held an impromptu news conference from the restaurant drive-thru. Trump’s team thinks people should get a sense of humor. “President Trump is a master at messaging and he’s always relatable to the average person, whereas many media members take themselves too seriously and have no concept of anything else other than suffering from Trump Derangement Syndrome,” said Steven Cheung, Trump’s communications director. “President Trump will Make America Great Again and we are getting back to a sense of optimism after a tumultuous four years.” Though both the Biden and Harris campaigns created and shared memes and launched other stunts to respond to Trump's taunts, so far America’s neighbors to the north are not taking the bait. “I don’t think we should necessarily look on Truth Social for public policy,” Miller said. Gerald Butts, a former top adviser to Trudeau and a close friend, said Trump brought up the 51st state line to Trudeau repeatedly during Trump’s first term in office. “Oh God,” Butts said Tuesday, “At least a half dozen times.” “This is who he is and what he does. He’s trying to destabilize everybody and make people anxious,” Butts said. “He’s trying to get people on the defensive and anxious and therefore willing to do things they wouldn’t otherwise entertain if they had their wits about them. I don’t know why anybody is surprised by it.” Gillies reported from Toronto. Associated Press writer Darlene Superville contributed to this report.
As they left the clinic, the sun was beginning to set, casting a golden glow over the city skyline. Zhang Meng and Xiao Wu walked side by side, their shadows merging into one, a symbol of their unbreakable bond and shared journey. The evening air was filled with laughter and chatter, a symphony of joy and contentment that seemed to envelop them in a bubble of happiness.
Hologic Statement on USPSTF Draft Cervical Cancer Screening Guidelines
In-Depth Analysis Of The Monoethanolamine Market: Key Drivers, Trends, Growth Opportunities, And Forecast 2024-2033
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